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Analytical dating between metrics from chemical substances bioaccumulation inside the seafood

Analytical dating between metrics from chemical substances bioaccumulation inside the seafood

Five widely used metrics of bioaccumulation in fish are defined and discussed, namely the octanol–water partition coefficient (KOW), bioconcentration factor (BCF), bioaccumulation factor (BAF), biomagnification factor (BMF), and trophic magnification factor (TMF). Algebraic relationships between these metrics are developed and discussed using conventional expressions for chemical uptake from water and food and first-order losses by respiration, egestion, biotransformation, and growth dilution. Two BCFs ely as an equilibrium partition coefficient KFW or as a nonequilibrium BCFK in which egestion losses are included. Bioaccumulation factors are shown to be the product of the BCFK and a ely, the diet-to-water concentration ratio and the ratio of uptake rate constants for respiration and dietary uptake. Biomagnification factors are shown to be proportional to the lipid-normalized ratio of the predator/prey values of BCFK and the ratio of the equilibrium multipliers. Relationships with TMFs are also discussed. The effects of chemical hydrophobicity, biotransformation, and growth are evaluated by applying the relationships to a range of illustrative chemicals of varying KOW in a linear 4-trophic-level food web with typical values for uptake and loss rate constants. The roles of respiratory and dietary intakes are demonstrated, and even slow rates of biotransformation and growth can significantly affect bioaccumulation. The BCFKs and the values of M can be regarded as the fundamental determinants of bioaccumulation and biomagnification in aquatic food webs. Analyzing data from food webs can be enhanced by plotting logarithmic lipid-normalized concentrations or fugacities as a linear function of trophic level to deduce TMFs. Implications for determining bioaccumulation by laboratory tests for regulatory purposes are discussed. Environ Toxicol Chem 2013;–1466. © 2013 SETAC


Bioaccumulation of organic chemical substances for the seafood and other bacteria that can create eating organizations is a problem on account of each other you can easily negative consequences to the organisms on their own as well as the possibility connection with predators, plus individuals, that consume these types of bacteria. The main focus here’s for the bioaccumulation within the seafood, but equivalent standards apply to bioaccumulation in other marine drinking water-respiration organisms, and they also may connect with heavens-respiration organisms particularly birds and you can animals. Thus, a worldwide step could have been revealed to evaluate industrial chemical compounds to have their power to bioaccumulate step 1, 2 . As an element of it initiative, different types of bioaccumulation research and you can metrics are acclimatized to dictate whether or not also to exactly what the amount agents is actually bioaccumulative. Detailed literary works can be found for the bioaccumulation off medical and you will regulating viewpoints, examples as the recommendations because of the Barber 3, cuatro , Mackay and you will Fraser 5 , Arnot and Gobas 6 , Ehrlich et al. 7 , Burkhard mais aussi al. 8 , and you may Gobas et al. 9 , aforementioned summarizing the newest conclusions out of a good SETAC-sponsored workshop held for the 2008. These and other product reviews features discussed the presence of several metrics out of bioaccumulation that differ for the definition, from inside the regulating app, along with adoption by medical area.

All of our purpose here is so you’re able to identify and you may talk about the relationship ranging from 5 common bioaccumulation metrics to have marine organisms having a viewpoint so you can making clear its relative deserves and you may usefulness to own bioaccumulation examination. We very first temporarily identify and you may discuss the bioaccumulation metrics, after that implement a bulk equilibrium design to examine and you may assess the latest dating between them. I seek to provide unique information toward underlying procedure resulting in the bioaccumulation and offer recommendations to own boosting and you can in search of study for bioaccumulation tests.


For the current analysis, we define and describe 5 common metrics for assessing bioaccumulation. Differences exist in the definitions and usage of these terms; however, the definitions given here are used to develop mathematical relationships in the next section. The octanol–water partition coefficient (KOW) is widely used as an indicator of hydrophobicity and thus the partitioning of a chemical from water into lipids and other organic phases such as protein 10 . The KOW is primarily controlled by the solubility of the substance in water, because the solubility of neutral, liquid nonpolar organic chemicals in octanol is relatively constant. A log KOW value of 5 is often used as a bioaccumulation assessment criterion; however, depending on the regulatory program, lower values are also used to categorize bioaccumulation potential. Whereas KOW gives a reasonable and conservative estimate of lipid–water partitioning for nonpolar hydrophobic substances 11 , it may not accurately simulate partitioning for more polar and ionogenic organic chemicals and other chemical classes such as organofluorines and silicones. Direct empirical measurement is essential in such cases.

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